Plasma-deposited fluorocarbon polymer films on titanium for preventing cell adhesion: a surface finishing for temporarily used orthopaedic implants

The design of a titanium implant surface should ideally support its later application in clinical use. Temporarily used implants have to fulfil requirements different from permanent implants: they should ensure the mechanical stabilization of the bone stock but in trauma surgery they should not be i...

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Bibliographic Details
Published in:Journal of physics. D, Applied physics Applied physics, 2016-06, Vol.49 (23), p.234002-234015
Main Authors: Finke, B, Testrich, H, Rebl, H, Walschus, U, Schlosser, M, Zietz, C, Staehlke, S, Nebe, J B, Weltmann, K D, Meichsner, J, Polak, M
Format: Article
Language:English
Subjects:
Biotechnology
Bones
Cell adhesion
cell anti-adhesive surface
Contact angle
investigations
microwave plasma
Osteoblasts
plasma fluorocarbon polymer
Radio frequencies
radio frequency plasma
Surgical implants
Titanium
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Summary:The design of a titanium implant surface should ideally support its later application in clinical use. Temporarily used implants have to fulfil requirements different from permanent implants: they should ensure the mechanical stabilization of the bone stock but in trauma surgery they should not be integrated into the bone because they will be removed after fracture healing. Finishing of the implant surface by a plasma-fluorocarbon-polymer (PFP) coating is a possible approach for preventing cell adhesion of osteoblasts. Two different low pressure gas-discharge plasma processes, microwave (MW 2.45 GHz) and capacitively coupled radio frequency (RF 13.56 MHz) plasma, were applied for the deposition of the PFP film using a mixture of the precursor octafluoropropane (C3F8) and hydrogen (H2). The thin films were characterized by x-ray photoelectron spectroscopy, Fourier transform infrared reflection absorption spectroscopy, and water contact angle measurements. Cell culture experiments show that cell adhesion and spreading of MG-63 osteoblasts were clearly reduced or nonexistent on these surfaces, also after 24 h of storage in the cell culture medium. In vivo data demonstrated that the local inflammatory tissue response for the PFP films deposited in MW and RF plasma were comparable to uncoated controls.
ISSN:0022-3727
1361-6463
DOI:10.1088/0022-3727/49/23/234002