super( times )OH and e super(-) sub(aq) are yet good candidates for demolishing the beta -lactam system of a penicillin eliminating the antimicrobial activity

Tracking the pharmacophore of a drug subjected to advanced oxidation is essential for evaluating the efficiency of the process in terms of wastewater treatment. From this standpoint, the super( times )OH and View the MathML source eaq- induced deactivation mechanism of amoxicillin, a penicillin deri...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2016-07, Vol.124, p.84-90
Main Authors: Szaboa, Laszlo, Tothb, Tuende, Racza, Gergely, Takacsa, Erzsebet, Wojnarovitsa, Laszlo
Format: Article
Language:English
Subjects:
Amoxicillin
Carbon
Deactivation
Oxidation
Penicillin
Pharmacology
Sulfur
Online Access:Get full text
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Summary:Tracking the pharmacophore of a drug subjected to advanced oxidation is essential for evaluating the efficiency of the process in terms of wastewater treatment. From this standpoint, the super( times )OH and View the MathML source eaq- induced deactivation mechanism of amoxicillin, a penicillin derivative was investigated in dilute aqueous solution using pulse- and gamma-radiolysis techniques. Based on IR measurements, super( times )OH and View the MathML source eaq- destroys the beta -lactam system of amoxicillin with ~55% and ~84% efficiency, respectively. In aerated solution the elimination of the pharmacophore was slightly impaired since the reaction pathway of the ring-opening was disturbed owing to the reactivity of O sub(2) and View the MathML source O2 times - toward the intermediates of sulfur oxidation. The high potency of View the MathML source eaq- for beta -lactam deactivation is attributed to the enhanced electron deficiency of the carbonyl carbon inside the lactam ring.
ISSN:0969-806X
DOI:10.1016/j.radphyschem.2015.10.012