Quantitative analysis of topical gels and ointments by FT-Raman spectroscopy

A method for quantitative determination of ibuprofen (IBU), naproxen (NAP), methyl salicylate (MES) and menthol (MNT) in commercial topical gels and ointments using partial least squares (PLS) models based on FT-Raman spectra is described. The calculated relative standard errors of prediction (RSEP)...

Full description

Saved in:
Bibliographic Details
Published in:Vibrational spectroscopy 2016-03, Vol.83, p.1-7
Main Authors: Mazurek, Sylwester, Szostak, Roman
Format: Article
Language:English
Subjects:
Economic conditions
Economics
Gels
Ibuprofen
Mathematical models
Multivariate calibration
Ointment
Quantitative analysis
Raman spectroscopy
Spectroscopy
Topical gel
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A method for quantitative determination of ibuprofen (IBU), naproxen (NAP), methyl salicylate (MES) and menthol (MNT) in commercial topical gels and ointments using partial least squares (PLS) models based on FT-Raman spectra is described. The calculated relative standard errors of prediction (RSEP) were found to be in the range of 2.1–3.2% for the calibration and validation data sets. Two commercial topical gels containing 5.0% of IBU and 10% of NAP (w/w), as well as one ointment containing 15% of MES and 10% of MNT (w/w) as active pharmaceutical ingredients (APIs), were successfully quantified using the developed models with recoveries in the 99.2–101.5% range. The proposed procedure can be used as a fast, reliable and economic method for the quantification of APIs in topical gels and ointments.
ISSN:0924-2031
1873-3697
DOI:10.1016/j.vibspec.2015.12.005