Quantitative analysis of topical gels and ointments by FT-Raman spectroscopy

A method for quantitative determination of ibuprofen (IBU), naproxen (NAP), methyl salicylate (MES) and menthol (MNT) in commercial topical gels and ointments using partial least squares (PLS) models based on FT-Raman spectra is described. The calculated relative standard errors of prediction (RSEP)...

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Published in:Vibrational spectroscopy 2016-03, Vol.83, p.1-7
Main Authors: Mazurek, Sylwester, Szostak, Roman
Format: Article
Language:English
Subjects:
Economic conditions
Economics
Gels
Ibuprofen
Mathematical models
Multivariate calibration
Ointment
Quantitative analysis
Raman spectroscopy
Spectroscopy
Topical gel
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description A method for quantitative determination of ibuprofen (IBU), naproxen (NAP), methyl salicylate (MES) and menthol (MNT) in commercial topical gels and ointments using partial least squares (PLS) models based on FT-Raman spectra is described. The calculated relative standard errors of prediction (RSEP) were found to be in the range of 2.1–3.2% for the calibration and validation data sets. Two commercial topical gels containing 5.0% of IBU and 10% of NAP (w/w), as well as one ointment containing 15% of MES and 10% of MNT (w/w) as active pharmaceutical ingredients (APIs), were successfully quantified using the developed models with recoveries in the 99.2–101.5% range. The proposed procedure can be used as a fast, reliable and economic method for the quantification of APIs in topical gels and ointments.
doi_str_mv 10.1016/j.vibspec.2015.12.005
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source ScienceDirect Freedom Collection
subjects Economic conditions
Economics
Gels
Ibuprofen
Mathematical models
Multivariate calibration
Ointment
Quantitative analysis
Raman spectroscopy
Spectroscopy
Topical gel
title Quantitative analysis of topical gels and ointments by FT-Raman spectroscopy
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