Chemiluminescent lateral-flow immunoassays by using in-situ synthesis of CdS NW photosensor

A hypersensitive CdS nanowire (NW) photosensor was fabricated by an in-situ synthesis process that involved the direct synthesis of CdS NWs on an interdigitated electrode (IDE). Analysis of the photoresponse properties showed that the newly synthesized photosensor had enhanced sensitivity and a high...

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Bibliographic Details
Published in:Analytica chimica acta 2016-07, Vol.927, p.99-106
Main Authors: An, Byoung-Gi, Kim, Hong-Rae, Kang, Min-Jung, Park, Jae-Gwan, Chang, Young Wook, Pyun, Jae-Chul
Format: Article
Language:English
Subjects:
Antigens
Cadmium Compounds - chemistry
CdS
Chemiluminescence
Electrodes
Hepatitis B
Hepatitis B Surface Antigens - analysis
Immunoassay
Immunoassay - methods
Interdigitated electrode
Light
Limit of Detection
Luminescence
Luminol - chemistry
Mathematical analysis
Nanowire
Nanowires
Photosensor
Reproducibility of Results
Selenium Compounds - chemistry
Synthesis
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Summary:A hypersensitive CdS nanowire (NW) photosensor was fabricated by an in-situ synthesis process that involved the direct synthesis of CdS NWs on an interdigitated electrode (IDE). Analysis of the photoresponse properties showed that the newly synthesized photosensor had enhanced sensitivity and a highly reproducible photoresponse compared to photosensors prepared from CdS NW suspensions. The NW photosensor was applied to measure the chemiluminescence of luminol, and the sensitivity was compared to a commercial photosensing system. Finally, the feasibility of the CdS NW photosensor for the application to the medical diagnosis of the human hepatitis B surface antigen (hHBsAg) was demonstrated using a lateral-flow immunoassay with a chemiluminescent signal band. [Display omitted] •A hypersensitive CdS nanowire (NW) photosensor was fabricated by the in-situ synthesis.•The in-situ synthesis involved direct synthesis of CdS NWs on interdigitated electrodes.•In-situ synthesized NW photosensor could highly enhance sensitivity and reproducibility.•The NW photosensor was applied to the chemiluminescent lateral flow immunoassay.•The medical diagnosis of the hepatitis B surface antigen (hHBsAg) was demonstrated.
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2016.04.048