Production of microparticles of PHBV polymer impregnated with progesterone by supercritical fluid technology

This work reports the synthesis of particles based on poly(3‐hydroxybutirate‐co‐3‐hydroxyvalerate) (PHBV) polymer that were impregnated with progesterone. The PHBV particles were obtained by supercritical CO2 (scCO2) anti‐solvent expansion (SAS). scCO2 was also used at a high pressure (25 MPa) and m...

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Bibliographic Details
Published in:Canadian journal of chemical engineering 2016-07, Vol.94 (7), p.1336-1341
Main Authors: Giufrida, Willyan Machado, Voll, Fernando A., Feihrmann, Andresa Carla, Kunita, Marcos H., Madureira, Ed H., Guilherme, Marcos R., Vedoy, Diógenes R. L., Cabral, Vladimir F., Cardozo-Filho, Lúcio
Format: Article
Language:English
Subjects:
Carbon dioxide
Chemical engineering
Illustrations
Impregnation
In vitro testing
Microparticles
PHBV
progesterone
supercritical CO2
Supercritical fluids
Synthesis
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Summary:This work reports the synthesis of particles based on poly(3‐hydroxybutirate‐co‐3‐hydroxyvalerate) (PHBV) polymer that were impregnated with progesterone. The PHBV particles were obtained by supercritical CO2 (scCO2) anti‐solvent expansion (SAS). scCO2 was also used at a high pressure (25 MPa) and moderate temperature (323 K) for the impregnation of progesterone into the PHBV particles at different impregnation times. In vitro release tests showed that the half‐time of progesterone release in a hydro‐alcoholic medium, for the samples produced with impregnation times of 2–32 h, was 3–5 h, with the higher release times generally related to smaller impregnation times. Illustration describing the steps for PHBV microparticle fabrication and impregnation with progesterone.
ISSN:0008-4034
1939-019X
DOI:10.1002/cjce.22511