Protamine coated proliposomes of recombinant human insulin encased in Eudragit S100 coated capsule offered improved peptide delivery and permeation across Caco-2 cells

In present investigation, recombinant human insulin loaded proliposomes and protamine sulphate coated proliposomes (rh insulin-proliposomes and Pt-rh insulin proliposomes) were encased in Eudragit S100 coated capsule to offer peptide release in simulated intestinal conditions. The particle size and...

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Bibliographic Details
Published in:Materials Science & Engineering C 2016-10, Vol.67, p.378-385
Main Authors: Sharma, Shiva, Jyoti, Kiran, Sinha, Richa, Katyal, Anju, Jain, Upendra Kumar, Madan, Jitender
Format: Article
Language:English
Subjects:
Caco-2 Cells
Casing (process)
Cellular
Cellular uptake
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacokinetics
Coated Materials, Biocompatible - pharmacology
Coating
Dichroism
Eudragit
Humans
Insulin
Insulin - chemistry
Insulin - pharmacokinetics
Insulin - pharmacology
Liposomes
Oral delivery
Peptides
Platinum
Polymethacrylic Acids - chemistry
Polymethacrylic Acids - pharmacokinetics
Polymethacrylic Acids - pharmacology
Proliposomes
Protamine
Protamines - chemistry
Protamines - pharmacokinetics
Protamines - pharmacology
Recombinant
rh insulin
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Summary:In present investigation, recombinant human insulin loaded proliposomes and protamine sulphate coated proliposomes (rh insulin-proliposomes and Pt-rh insulin proliposomes) were encased in Eudragit S100 coated capsule to offer peptide release in simulated intestinal conditions. The particle size and zeta potential of Pt-rh insulin proliposomes were measured to be 583.2±10.2nm/+28.3±3.7mV significantly (P
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2016.05.010