The Synthesis of Agent Produced by Interaction of the Complex Trans-Dichlorodiamminplatinum(II) with Arabinogalactan and its Properties

The obtained new product of reaction of the complex trans-dichlorodiaminplatinum(II) with arabinogalactan was characterized by XRD, IR-spectroscopy, UF-spetrophotometry and thermogravimetry. The composition and structure of this product was studied. It has been shown that trans-dichlorodiaminplatinu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Siberian Federal University. Chemistry 2016-01, Vol.9 (1), p.42-48
Main Authors: Starkov, Alexander K, Kozuchovskaya, Galina A, Pavlenko, Nina I
Format: Article
Language:eng ; rus
Subjects:
Anticancer properties
Hydrogen
Pharmacology
Synthesis
Thermogravimetry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The obtained new product of reaction of the complex trans-dichlorodiaminplatinum(II) with arabinogalactan was characterized by XRD, IR-spectroscopy, UF-spetrophotometry and thermogravimetry. The composition and structure of this product was studied. It has been shown that trans-dichlorodiaminplatinum(II) associated with arabinogalactan through - C-O-C- amino hydrogen of the original complex. The synthesized product has the improved pharmacological properties being more soluble, less toxic and shows a greater anticancer activity as compared to cis-dichlorodiaminplatinum(II).
ISSN:1998-2836
2313-6049
DOI:10.17516/1998-2836-2016-9-1-42-48