Markovnikov addition of imidazole derivatives with vinyl esters catalyzed by lipase TL IM from Thermomyces lanuginosus/K sub(2)CO sub(3) in a continuous-flow microreactor

In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K sub(2)CO sub(3) in a continuous-flow microreactor was described. The effects of the mixed catalysts, molar ratio and the structure of reactants on the reaction...

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Bibliographic Details
Published in:RSC advances 2016-06, Vol.6 (64), p.59100-59103
Main Authors: Du, Li-Hua, Cheng, Bing-Zhuo, Yang, Wen-Jun, Xu, Liang-Liang, Luo, Xi-Ping
Format: Article
Language:English
Subjects:
Catalysis
Derivatives
Imidazole
Lipase
Microreactors
Reaction time
Reactors
Thermomyces lanuginosus
Vinyl ester resins
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Summary:In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K sub(2)CO sub(3) in a continuous-flow microreactor was described. The effects of the mixed catalysts, molar ratio and the structure of reactants on the reaction performance were experimentally studied. The attractive features of this process are shorter reaction times (30 min) and excellent yields compared to that in shaker reactors.
ISSN:2046-2069
DOI:10.1039/c6ra05983j