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Physicochemical characterization and decomposition kinetics of (S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole HCl/S-enantiomer of medetomidineHCl

Physicochemical characterization of ( S )-4-[1-(2,3-dimethylphenyl)ethyl]- 3H -imidazole HCl in solution as well as the solid state has been done using single-crystal X-ray crystallography, 1 H and 13 C NMR, IR and mass spectrometry. The single-crystal structure, as well as Hirshfeld surface analysi...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2016-04, Vol.124 (1), p.269-278
Main Authors: Pansuriya, Pramod B., Maguire, Glenn E. M., Friedrich, Holger B.
Format: Article
Language:English
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Summary:Physicochemical characterization of ( S )-4-[1-(2,3-dimethylphenyl)ethyl]- 3H -imidazole HCl in solution as well as the solid state has been done using single-crystal X-ray crystallography, 1 H and 13 C NMR, IR and mass spectrometry. The single-crystal structure, as well as Hirshfeld surface analysis, of the S-enantiomer is compared with the racemate, as well as the polymorph of the racemate. The decomposition kinetics of the S-enantiomer have been studied using thermogravimetric analysis and a differential scanning calorimetric investigation. The study was done to contribute to understanding the properties of the drug at a molecular level, thus providing tools to develop novel formulations of the drug.
ISSN:1388-6150
1588-2926
1572-8943
DOI:10.1007/s10973-015-5086-y