Protein/peptide secondary structural mimics: design, characterization, and modulation of protein-protein interactions

Protein-protein interactions (PPIs) play a critical role in many essential biological processes, and numerous diseases result from malfunctioning PPIs. The modulation of undesirable PPIs via synthetic chemical molecules has long been considered of medical importance, but still remains challenging. T...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (66), p.61599-6169
Main Authors: Wang, Zhipeng A, Ding, Xiaozhe Z, Tian, Chang-Lin, Zheng, Ji-Shen
Format: Article
Language:English
Subjects:
Biological activity
Chemists
Diseases
Modulation
Peptides
Proteins
Structural analysis
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Summary:Protein-protein interactions (PPIs) play a critical role in many essential biological processes, and numerous diseases result from malfunctioning PPIs. The modulation of undesirable PPIs via synthetic chemical molecules has long been considered of medical importance, but still remains challenging. Thanks to the development of synthetic chemistry, chemists can synthesize protein/peptide secondary structure mimics to modulate the specific PPIs. This review discusses general aspects of novel artificial peptide secondary structure mimics for the modulation of PPIs, their therapeutic applications and future prospects. This review discusses general aspects of novel artificial peptide secondary structure mimics for modulation of PPIs, their therapeutic applications and future prospects.
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra13976k