Quantitative determination of hydroxy polycylic aromatic hydrocarbons as a biomarker of exposure to carcinogenic polycyclic aromatic hydrocarbons

•A new HRGC–HRMS method was developed for determination of 4 OH-PAHs.•The causes of OH-PAHs instability were identified as photo induced oxidation.•The current method controlled OH-PAH analyte degradation during analysis.•Conjugated OH-PAHs are more stable than non-conjugated OH-PAHs.•Accuracy and p...

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Bibliographic Details
Published in:Journal of Chromatography A 2016-07, Vol.1454, p.93-100
Main Authors: Woudneh, Million B., Benskin, Jonathan P., Grace, Richard, Hamilton, M.Coreen, Magee, Brian H., Hoeger, Glenn C., Forsberg, Norman D., Cosgrove, John R.
Format: Article
Language:English
Subjects:
Antioxidants
Biomarkers
Biomonitoring
Carcinogens
Exposure
GC–HRMS
Liquids
Mice
OH-PAHs
Polycyclic aromatic hydrocarbons
Quantitative analysis
Stability
Urine
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Summary:•A new HRGC–HRMS method was developed for determination of 4 OH-PAHs.•The causes of OH-PAHs instability were identified as photo induced oxidation.•The current method controlled OH-PAH analyte degradation during analysis.•Conjugated OH-PAHs are more stable than non-conjugated OH-PAHs.•Accuracy and precision were 77.4–117% (
ISSN:0021-9673
DOI:10.1016/j.chroma.2016.05.057