Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of nine local anesthetic drugs

Highlights • A simultaneous determination of nine local anesthetics using LC/MS/MS was developed. • The solid-phase extraction well recovered the drugs from human serum. • The separation and sensitivity of nine local anesthetics by LC/MS/MS were sufficient. • This method would be useful for the anal...

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Bibliographic Details
Published in:Forensic science international 2016-08, Vol.265, p.182-185
Main Authors: Tonooka, Keiko, Naruki, Nobuhiko, Honma, Kou, Agei, Kohei, Okutsu, Mayumi, Hosono, Tetsuji, Kunisue, Yoko, Terada, Masaru, Tomobe, Koji, Shinozuka, Tatsuo
Format: Article
Language:English
Subjects:
Anesthesia
Anesthetics
Anesthetics, Local - blood
Calibration
Chemicals
Chromatography
Chromatography, Liquid
Drugs
Experiments
Extraction
Forensic engineering
Forensic sciences
Forensic Toxicology
Humans
Ions
Isotopes
LC/MS/MS, Local anesthetic, Analysis, Solid phase extraction
Liquid chromatography
Mass spectrometry
Pathology
Predictive Value of Tests
Scientific imaging
Serums
Substance Abuse Detection - methods
Substance-Related Disorders - blood
Substance-Related Disorders - diagnosis
Tandem Mass Spectrometry
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Summary:Highlights • A simultaneous determination of nine local anesthetics using LC/MS/MS was developed. • The solid-phase extraction well recovered the drugs from human serum. • The separation and sensitivity of nine local anesthetics by LC/MS/MS were sufficient. • This method would be useful for the analysis of local anesthetics in forensic cases.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2016.02.044