A novel and efficient methodology for thio-Michael addition in the synthesis of cis-β-thio-α-aminoacid derivatives using Zn[( l )-Pro] 2 as heterogeneous catalyst

A simple, efficient and green chemical ultrasound assisted thio-Michael addition reaction between thiols and ( Z )-azlactones aiming to produce non-natural amino acid derivatives by using chiral Zn[( l )-Pro] 2 as a heterogeneous catalyst is herein described. The product was obtained in good to exce...

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Bibliographic Details
Published in:RSC advances 2016, Vol.6 (6), p.4979-4982
Main Authors: Rocha, M. P. D., Oliveira, A. R., Albuquerque, T. B., da Silva, C. D. G., Katla, R., Domingues, N. L. C.
Format: Article
Language:English
Subjects:
Amino acids
Catalysts
Chemical reactions
Derivatives
Methodology
Synthesis
Thiols
Ultrasound
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Summary:A simple, efficient and green chemical ultrasound assisted thio-Michael addition reaction between thiols and ( Z )-azlactones aiming to produce non-natural amino acid derivatives by using chiral Zn[( l )-Pro] 2 as a heterogeneous catalyst is herein described. The product was obtained in good to excellent yields presenting high diastereoselectivity.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA26324G