Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs

Mitochondria are dynamic double-membrane bound organelles which have key roles in a variety of cellular functions such as energy producing, regulation of calcium flux, cellular stress responses including autophagy and apoptosis. A growing body of evidence indicates that mitochondrial dysfunction is...

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Bibliographic Details
Published in:Biotechnology advances 2016-09, Vol.34 (5), p.813-826
Main Authors: de Oliveira, Marcos Roberto, Jardim, Fernanda Rafaela, Setzer, William N, Nabavi, Seyed Mohammad, Nabavi, Seyed Fazel
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bioavailability
Cell Line
Cellular
Curcuma longa
Curcumin - chemistry
Curcumin - metabolism
Curcumin - pharmacology
Diseases
Dynamics
Humans
Medical services
Mice
Mitochondria
Mitochondria - drug effects
Mitochondria - physiology
Mitochondrial Degradation - drug effects
Mitochondrial Degradation - physiology
Neurological diseases
Organelle Biogenesis
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Summary:Mitochondria are dynamic double-membrane bound organelles which have key roles in a variety of cellular functions such as energy producing, regulation of calcium flux, cellular stress responses including autophagy and apoptosis. A growing body of evidence indicates that mitochondrial dysfunction is the main culprit in a myriad of diseases such as neurodegenerative disease. This fact opens a new therapeutic window based on targeting mitochondrial dysfunction for treatment of these diseases. Recently an abundance of evidence shows the promising role of polyphenolic compounds on mitochondrial structure and function. Curcumin, a well-known polyphenolic compound, is an abundant component of turmeric. The promising roles of curcumin against different diseases are highly publicized. The aim of the present work is to critically review the scientific evidence to provide a clear view of how curcumin improves mitochondrial dynamics regarding mitochondrial biogenesis and mitophagy. We also present curcumin biosynthesis, source, bioavailability and metabolism in order to give an overview of this compound.
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2016.04.004