TGF-β signaling: positive and negative effects on tumorigenesis

TGF-β binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity...

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Bibliographic Details
Published in:Current Opinion in Genetics & Development 2002-02, Vol.12 (1), p.22-29
Main Authors: Wakefield, Lalage M, Roberts, Anita B
Format: Article
Language:English
Subjects:
Animals
DNA-Binding Proteins - metabolism
Gene Dosage
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
MAPK
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - metabolism
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Receptors, Transforming Growth Factor beta - metabolism
signal transduction
Signal Transduction - physiology
Smad
TGF-β
Transcription, Genetic
Transcriptional Activation
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta - metabolism
Transforming Growth Factor beta - physiology
tumorigenesis
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Summary:TGF-β binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathways may underlie the complex transition of the TGF-β pathway from tumor suppressor to oncogene during tumorigenesis.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(01)00259-3