Tumor vascularity in ovarian cancer: T cells need breathing room

Tumor-infiltrating lymphocytes (TILs) are crucial for effective antitumor responses. However, hypoxia can skew T-cell differentiation and function, thereby perturbing TILs. We have demonstrated that TILs and their immune function are associated with tumor vascularization. These features are prognost...

Full description

Saved in:
Bibliographic Details
Published in:Oncoimmunology 2014-04, Vol.3 (4), p.e28272-e28272
Main Authors: Neilson, David, MacPherson, Sarah, Townsend, Katelin N, Lum, Julian J
Format: Article
Language:English
Subjects:
Author's View
autophagy
CD31
hypoxia
ovarian cancer
T cell
VEGF
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumor-infiltrating lymphocytes (TILs) are crucial for effective antitumor responses. However, hypoxia can skew T-cell differentiation and function, thereby perturbing TILs. We have demonstrated that TILs and their immune function are associated with tumor vascularization. These features are prognostic for improved disease-specific survival in ovarian cancer. Thus, new immunotherapies should consider how hypoxia impacts antitumor immunity.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.28272