Improved surgical outcomes for hilar cholangiocarcinoma: changes in surgical procedures and related outcomes based on 40 years of experience at a single institution

Purpose This study aimed to examine the changes in procedures for hilar cholangiocarcinoma (HC) surgery and patient survival following HC surgery over a 40-year period. Methods Between 1974 and 2014, 239 consecutive patients underwent surgery for HC. The changes in perioperative therapy and short- a...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2016-01, Vol.46 (1), p.74-83
Main Authors: Higuchi, Ryota, Ota, Takehiro, Yazawa, Takehisa, Kajiyama, Hideki, Araida, Tatsuo, Furukawa, Toru, Yoshikawa, Tatsuya, Takasaki, Ken, Yamamoto, Masakazu
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Original Article
Surgery
Surgical Oncology
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Summary:Purpose This study aimed to examine the changes in procedures for hilar cholangiocarcinoma (HC) surgery and patient survival following HC surgery over a 40-year period. Methods Between 1974 and 2014, 239 consecutive patients underwent surgery for HC. The changes in perioperative therapy and short- and long-term surgical outcomes were evaluated. Results The rates of major hepatectomy (in particular, right hepatectomy) and R0 resection significantly increased. Blood loss, transfusion rate, morbidity, and surgical mortality all significantly decreased. The 5-year disease-specific survival was 9.29 % ( n  = 38) in 1974–1988, 41.1 % ( n  = 88) in 1989–2003 and 55.6 % ( n  = 57) in 2004–2008 ( p  = 0.0001: 1974–1988 vs 1989–2003, p  
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-015-1119-1