Targeting Galectin-1 in pancreatic cancer: immune surveillance on guard

The tumor microenviroment and immune barrier are known to modulate malignant disease progression. We have recently identified Galectin-1 as a key player in a novel stromal regulatory reaction driving immune evasion in pancreatic tumors in vivo. These results suggest that Galectin-1 inhibition repres...

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Bibliographic Details
Published in:Oncoimmunology 2014-08, Vol.3 (8), p.e952201-e952201
Main Authors: Martínez-Bosch, Neus, Navarro, Pilar
Format: Article
Language:English
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Galectin-1
immune evasion
immunosurveillance
pancreatic cancer
stroma
tumor microenvironment
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Summary:The tumor microenviroment and immune barrier are known to modulate malignant disease progression. We have recently identified Galectin-1 as a key player in a novel stromal regulatory reaction driving immune evasion in pancreatic tumors in vivo. These results suggest that Galectin-1 inhibition represents a potential therapeutic strategy for one of the most deadly types of cancer.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/21624011.2014.952201