Prognostic value of preoperative N-terminal pro-brain natriuretic peptide in non-cardiac surgery of elderly patients with normal left ventricular systolic function

Aim We investigated the prognostic value of preoperative N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) in non‐cardiac surgery in elderly patients who showed normal left ventricular function on preoperative echocardiography. Methods We analyzed 1459 patients aged older than 70 years who had co...

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Bibliographic Details
Published in:Geriatrics & gerontology international 2016-10, Vol.16 (10), p.1109-1116
Main Authors: Kim, In Jai, Moon, Jae Youn, Ko, Eun-Jung, Lim, Yeong-Min, Kim, Sang Hoon, Yang, Woo-In, Sung, Jung-Hoon, Lim, Sang-Wook, Cha, Dong-Hun
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers - blood
Cardiac arrhythmia
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cohort Studies
echocardiography
Echocardiography - methods
elderly
Female
Gerontology
heart failure
Humans
Male
Medical prognosis
Multivariate Analysis
N-terminal pro-brain natriuretic peptide
Natriuretic Peptide, Brain - blood
non-cardiac surgery
Odds Ratio
Peptides
Postoperative Complications - diagnosis
Postoperative Complications - epidemiology
Predictive Value of Tests
Preoperative Care - methods
Prognosis
Risk Assessment
Risk factors
ROC Curve
Surgery
Surgical Procedures, Operative - adverse effects
Surgical Procedures, Operative - methods
Ultrasonic imaging
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Function, Left - physiology
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Summary:Aim We investigated the prognostic value of preoperative N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) in non‐cardiac surgery in elderly patients who showed normal left ventricular function on preoperative echocardiography. Methods We analyzed 1459 patients aged older than 70 years who had consulted a cardiologist for the evaluation of cardiovascular risk for non‐cardiac surgery. Of the 721 patients who simultaneously underwent echocardiography and NT‐proBNP assessments, 506 who showed normal left ventricular systolic function were included. The predictive power of NT‐proBNP for the risk of major adverse cardiac and cerebrovascular events (MACCE) was evaluated. Results MACCE occurred in 40 (7.9%) of the 506 patients, and the median value of NT‐proBNP was higher in patients with complications than in those without (MACCE group: 1700.5 pg/mL vs non MACCE group: 206.35 pg/mL; P 
ISSN:1444-1586
1447-0594
DOI:10.1111/ggi.12597