Helicobacter pylori infection and gastroesophageal reflux in children

• Published in: Diseases of the esophagus 2016-11, Vol.29 (8), p.1007-1012
• Main Authors: Lupu, V. V., Ignat, A., Ciubotariu, G., Ciubară, A., Moscalu, M., Burlea, M.
• Format: Article
• Language: English
• Subjects: 24‐hour pH‐metry; Case-Control Studies; Child; children; Endoscopy, Digestive System; Esophageal pH Monitoring; Esophagitis, Peptic - classification; Esophagitis, Peptic - epidemiology; gastroesophageal reflux; Gastroesophageal Reflux - epidemiology; Helicobacter Infections - epidemiology; Helicobacter pylori; Humans; Romania - epidemiology; Severity of Illness Index; Stomach - microbiology; Stomach - pathology
• ISSN: 1120-8694; 1442-2050
• DOI: 10.1111/dote.12429

Summary Some studies suggest that Helicobacter pylori (H. pylori) infection would be a protective factor for the gastroesophageal reflux. The aim of this study was to explore this fact. A group of 72 children, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with gastroesophageal reflux by 24‐hour continuous esophageal pH monitoring (results were interpreted using the Boix‐Ochoa score), underwent upper endoscopy with gastric biopsy to detect the presence of H. pylori by the rapid urease testing and for bacteriological and histologic examination. 19 children (26.39%) had H. pylori infection, while 53 (73.61%) did not. The grade of esophagitis was classified according to the Los Angeles classification system. Out of 47 children with esophagitis A, 16 (34.04%) had H. pylori infection, while out of the 25 children with esophagitis B, only 3 (12%) had H. pylori infection, with statistic significance (χ2 = 54.69, P