Disruption of pre-B-cell receptor signaling jams the WNT/β-catenin pathway and induces cell death in B-cell acute lymphoblastic leukemia cell lines

Highlights • Enzastaurin induces apoptosis and cell cycle arrest in B-ALL cell lines. • Targeting PKCβ with enzastaurin inhibits AKT, GSK3β, and β-catenin phosphorylation. • PKCβ inhibition results in significant accumulation of β-catenin. • p73 isoforms are protected following PKCβ inhibition throu...

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Bibliographic Details
Published in:Leukemia research 2015-11, Vol.39 (11), p.1220-1228
Main Authors: Saba, Nakhle S, Angelova, Magdalena, Lobelle-Rich, Patricia A, Levy, Laura S
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Catenin
Enzastaurin
Hematology, Oncology and Palliative Medicine
JUN
MYC
Protein kinase Cβ
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Summary:Highlights • Enzastaurin induces apoptosis and cell cycle arrest in B-ALL cell lines. • Targeting PKCβ with enzastaurin inhibits AKT, GSK3β, and β-catenin phosphorylation. • PKCβ inhibition results in significant accumulation of β-catenin. • p73 isoforms are protected following PKCβ inhibition through upregulation of c-Jun.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.08.002