Shell Cleavable Dendritic Polyglycerol Sulfates Show High Anti-Inflammatory Properties by Inhibiting L-Selectin Binding and Complement Activation

A new class of fully synthetic shell cleavable multivalent polysulfates is prepared by introducing degradable linkers into a stable biocompatible dendritic polyglycerol scaffold and subsequent sulfation. The sulfated polymers show different degradation profiles, low anticoagulant and high anti‐infla...

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Bibliographic Details
Published in:Advanced healthcare materials 2015-10, Vol.4 (14), p.2154-2162
Main Authors: Reimann, Sabine, Gröger, Dominic, Kühne, Christian, Riese, Sebastian B., Dernedde, Jens, Haag, Rainer
Format: Article
Language:English
Subjects:
Activation
Binding
Complement
Degradation
dendritic polyglycerol sulfate
Health care
inflammation targeting
Polyglycerols
Polymers
Sulfation
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Summary:A new class of fully synthetic shell cleavable multivalent polysulfates is prepared by introducing degradable linkers into a stable biocompatible dendritic polyglycerol scaffold and subsequent sulfation. The sulfated polymers show different degradation profiles, low anticoagulant and high anti‐inflammatory properties, are able to efficiently bind to L‐selectin and inhibit the complement activation at very low concentrations in vitro.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201500503