Substance use disorder and risk of suicidal ideation, suicide attempt and suicide death: a meta-analysis

This meta-analysis addressed the association between substance use disorder (SUD) and suicide outcomes based on current evidence. We searched PubMed, Web of Science and Scopus until May 2015. We also searched the reference lists of included studies and Psycinfo website. We included observational (co...

Full description

Saved in:
Bibliographic Details
Published in:Journal of public health (Oxford, England) England), 2016-09, Vol.38 (3), p.e282-e291
Main Authors: Poorolajal, Jalal, Haghtalab, Tahereh, Farhadi, Mehran, Darvishi, Nahid
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Child
Child, Preschool
Female
Humans
LIFE COURSE & EPIDEMIOLOGY (ONLINE ONLY)
Male
Middle Aged
Risk Factors
Sex Factors
Substance-Related Disorders - epidemiology
Substance-Related Disorders - psychology
Suicidal Ideation
Suicide - psychology
Suicide - statistics & numerical data
Suicide, Attempted - psychology
Suicide, Attempted - statistics & numerical data
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This meta-analysis addressed the association between substance use disorder (SUD) and suicide outcomes based on current evidence. We searched PubMed, Web of Science and Scopus until May 2015. We also searched the reference lists of included studies and Psycinfo website. We included observational (cohort, case-control, cross-sectional) studies addressing the association between SUD and suicide. Our outcomes of interest were suicide ideation, suicide attempt and suicide death. For each outcome, we calculated the odds ratio (OR) or risk ratio (RR) with 95% confidence intervals (CI) based on the random-effects model. We identified a total of 12 413 references and included 43 studies with 870 967 participants. There was a significant association between SUD and suicidal ideation: OR 2.04 (95% CI: 1.59, 2.50; I = 88.8%, 16 studies); suicide attempt OR 2.49 (95% CI: 2.00, 2.98; I = 94.3%, 24 studies) and suicide death OR 1.49 (95% CI: 0.97, 2.00; I = 82.7%, 7 studies). Based on current evidence, there is a strong association between SUD and suicide outcomes. However, evidence based on long-term prospective cohort studies is limited and needs further investigation. Moreover, further evidence is required to assess and compare the association between suicide outcomes and different types of illicit drugs, dose-response relationship and the way they are used.
ISSN:1741-3842
1741-3850
DOI:10.1093/pubmed/fdv148