Quantitative susceptibility mapping at 3 T: comparison of acquisition methodologies

• Published in: NMR in biomedicine 2017-04, Vol.30 (4), p.n/a
• Main Authors: Lauzon, M. Louis, McCreary, Cheryl R., McLean, D. Adam, Salluzzi, Marina, Frayne, Richard
• Format: Article
• Language: English
• Subjects: Aged; Algorithms; Brain - anatomy & histology; Brain Chemistry; Female; gradient‐warp correction; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; methodology; Middle Aged; parallel imaging; QSM; readout gradient polarity; Reproducibility of Results; Sensitivity and Specificity; susceptibility
• ISSN: 0952-3480; 1099-1492
• DOI: 10.1002/nbm.3492

Quantitative susceptibility mapping (QSM) is fast becoming a routine clinical tool in the evaluation and assessment of neurological diseases. Unfortunately, there is currently no established standard scanning protocol, and it is uncertain whether different acquisition strategies alter the derived estimates of magnetic susceptibility. Here, we compare some key deep grey matter susceptibility values in healthy adults acquired from various QSM sequences using either unipolar or bipolar readout gradients, accelerated imaging or not, and gradient‐warp correction or not. Four healthy adult volunteers were scanned three times each within 4 days at 3 T. The eight different QSM combinations were acquired in different randomised order for each session, and then co‐registered to an anatomical atlas. The average and standard deviations of magnetic susceptibilities in the caudate, putamen, red nucleus, internal and external globus pallidus were used in a linear mixed effects model to determine the influence of the various acquisition parameters. Gradient‐warp correction was the only statistically significant fixed effect (p