Relationship between thioredoxin and thioredoxin-binding protein in patients with gestational diabetes mellitus

Objective: This study examined the clinical and biological significance of thioredoxin (Trx) and thioredoxin-binding protein (TrxBP), which are redox-active proteins that control multiple biological functions, in gestational diabetes. Methods: We measured serum concentrations of Trx, TrxBP, insulin...

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Published in:The journal of maternal-fetal & neonatal medicine 2017-01, Vol.30 (2), p.164-168
Main Authors: Eren, Esin, Aykal, Guzin, Sayrac, Suha, Erol, Onur, Ellidag, Hamit Yasar, Yilmaz, Necat
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - metabolism
Carrier Proteins - blood
Case-Control Studies
Diabetes, Gestational - metabolism
Female
Gestational diabetes
glucose metabolism
glucotoxicity
Humans
Insulin - blood
Insulin Resistance
Multivariate Analysis
Oxidative Stress
Pregnancy
Pregnancy Trimester, Second - metabolism
Prospective Studies
Statistics, Nonparametric
thioredoxin
thioredoxin-binding protein
Thioredoxins - blood
Young Adult
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Summary:Objective: This study examined the clinical and biological significance of thioredoxin (Trx) and thioredoxin-binding protein (TrxBP), which are redox-active proteins that control multiple biological functions, in gestational diabetes. Methods: We measured serum concentrations of Trx, TrxBP, insulin and other blood parameters, as well as insulin resistance and glucose tolerance in pregnant women with or without gestational dieabetes mellitus (GDM) (34/34) at the early second trimester. Results: Contrary to diabetes patients, serum TrxBP levels were lower in women with GDM than healthy pregnant controls. The serum insulin concentrations were higher in GDM, but the difference was not statistically significant. Furthermore, the intracellular redox potential ratio (Trx/TrxBP) of GDM patients was higher than that of the control group. Conclusion: During pregnancy, the mother is potentially subjected to glucotoxicity as well as oxidative stress (OS) to help the foetus absorb more nutrients. Our results suggest that the Trx/TrxBP system may mediate a compensating mechanism. Reduced TrxBP levels and consequent enhanced Trx activity may alleviate OS and protect the foetus from hypoglycaemia. We hypothesise that the decrease in TrxBP levels is not a consequence of GDM, but rather is an instance of the active functional role of TrxBP in maternal development, unifying redox regulation and glucose metabolism.
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2016.1163685