Risk of recurrence of idiopathic calcium kidney stones: analysis of data from the literature

Background Nephrolithiasis is a frequent condition. While it is generally accepted that such condition carries a risk of recurrence over time, the exact risk and its predictors have been rarely quantitated. We aimed to estimate recurrence of kidney stones, overall and in specific subgroups, from ran...

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Bibliographic Details
Published in:Journal of nephrology 2017-04, Vol.30 (2), p.227-233
Main Authors: Ferraro, Pietro Manuel, Curhan, Gary C., D’Addessi, Alessandro, Gambaro, Giovanni
Format: Article
Language:English
Subjects:
Calcium - metabolism
Humans
Kidney Calculi - epidemiology
Kidney Calculi - metabolism
Kidney Calculi - therapy
Medicine
Medicine & Public Health
Nephrology
Original Article
Randomized Controlled Trials as Topic
Recurrence
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Urology
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Summary:Background Nephrolithiasis is a frequent condition. While it is generally accepted that such condition carries a risk of recurrence over time, the exact risk and its predictors have been rarely quantitated. We aimed to estimate recurrence of kidney stones, overall and in specific subgroups, from randomized controlled trials (RCTs) of calcium stone formers. Methods Systematic review of RCTs of adult patients with idiopathic calcium kidney stones. Recurrence rates analyzed in subgroups based on type of intervention and other characteristics, using Poisson regression models. Results The analysis included 21 RCTs with 2168 participants over a median follow-up of 3.2 years (range 0.5–9.7). The median recurrence of kidney stones was 15 per 100 person–years (range 0–110). Recurrence was higher in those with two or more previous stone episodes compared to those with a single episode at enrolment (16 vs. 6 per 100 person–years, p 
ISSN:1121-8428
1724-6059
DOI:10.1007/s40620-016-0283-8