Effect of IGF-I and TNF-α on intensification of steroid pathways in women with PCOS phenotypes are not identical. Enhancement of progesterone pathway in women with PCOS increases the concentration of TNF-α

• Published in: Gynecological endocrinology 2016-09, Vol.32 (9), p.714-717
• Main Authors: Szczuko, M., Zapałowska-Chwyć, M., Drozd, A., Maciejewska, D., Starczewski, A., Stachowska, E.
• Format: Article
• Language: English
• Subjects: Adult; Androgens; Androgens - blood; Female; Humans; IGF-1; Insulin-Like Growth Factor I - metabolism; Middle Aged; ovary; Phenotype; polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; TNF-α; Tumor Necrosis Factor-alpha - blood
• ISSN: 0951-3590; 1473-0766
• DOI: 10.3109/09513590.2016.1159672

Objective: The aim of this study was to determine the correlations between the concentration of tumor necrosis factor (TNF-α) and insulin-like growth factor I (IGF-I) in each woman with polycystic ovary syndrome (PCOS) phenotypes based on the levels of androgen. Methods: Two groups of women with PCOS differing in their levels of androgens. The test group composed of 39 women with PCOS according to the Rotterdam criteria in their reproductive age. The hormonal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid stimulating hormone (TSH), prolactin (PRL), androstenedione, testosterone (T), estradiol (E 2 ) and sex hormone binding globulin (SHBG) were measured. Correlations analysis were performed calculating Spearman's rank correlation coefficient of hormones with relation to TNF-α and IGF-I. Results: There was a medium positive correlation of IGF-1 with LH levels (p