Inactivation of the orbitofrontal cortex reduces irrational choice on a rodent Betting Task

Highlights • The rodent Betting Task (rBT) probes the ‘escalation of commitment’ bias. • Pharmacological inactivation of the lOFC, but not IL or PL, mitigates this bias. • The lOFC’s role in subjective value judgments may contribute to this bias.

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Bibliographic Details
Published in:Neuroscience 2017-03, Vol.345, p.38-48
Main Authors: Barrus, M.M, Hosking, J.G, Cocker, P.J, Winstanley, C.A
Format: Article
Language:English
Subjects:
Animals
Baclofen - pharmacology
baclofen-muscimol
Choice Behavior - physiology
decision making
GABA-A Receptor Agonists - pharmacology
GABA-B Receptor Agonists - pharmacology
gambling
Gambling - physiopathology
impulsivity
infralimbic
Judgment - physiology
Limbic Lobe - drug effects
Limbic Lobe - physiopathology
Male
Muscimol - pharmacology
Neurology
Neuropsychological Tests
Prefrontal Cortex - drug effects
Prefrontal Cortex - physiopathology
prelimbic
Rats, Long-Evans
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Summary:Highlights • The rodent Betting Task (rBT) probes the ‘escalation of commitment’ bias. • Pharmacological inactivation of the lOFC, but not IL or PL, mitigates this bias. • The lOFC’s role in subjective value judgments may contribute to this bias.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.028