Ascorbylperoxide Contaminating Parenteral Nutrition Is Associated With Bronchopulmonary Dysplasia or Death in Extremely Preterm Infants

Background: Ascorbylperoxide (AscOOH) is a hydrogen peroxide–dependent by-product of ascorbic acid that contaminates parenteral nutrition. In a guinea pig model, it caused oxidized redox potential, increased apoptosis, and decreased alveolarization. AscOOH detoxification is carried out by glutathion...

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Bibliographic Details
Published in:JPEN. Journal of parenteral and enteral nutrition 2017-08, Vol.41 (6), p.1023-1029
Main Authors: Mohamed, Ibrahim, Elremaly, Wesam, Rouleau, Thérèse, Lavoie, Jean-Claude
Format: Article
Language:English
Subjects:
Ascorbic Acid - adverse effects
Ascorbic Acid - analogs & derivatives
Ascorbic Acid - urine
ascorbylperoxide
bronchopulmonary dysplasia
Bronchopulmonary Dysplasia - diagnosis
Bronchopulmonary Dysplasia - etiology
Bronchopulmonary Dysplasia - urine
Female
glutathione
Glutathione - blood
Glutathione Peroxidase - blood
Glutathione Reductase - blood
Humans
Incidence
Infant
Infant Mortality
Infant, Extremely Premature - blood
Infant, Extremely Premature - urine
Infant, Newborn
Male
oxidative stress
Parenteral Nutrition
Peroxides - adverse effects
Peroxides - urine
preterm infant
Prospective Studies
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Summary:Background: Ascorbylperoxide (AscOOH) is a hydrogen peroxide–dependent by-product of ascorbic acid that contaminates parenteral nutrition. In a guinea pig model, it caused oxidized redox potential, increased apoptosis, and decreased alveolarization. AscOOH detoxification is carried out by glutathione peroxidase (GPX). We hypothesize that extremely preterm infants have limited capacity for AscOOH detoxification. Our objective was to determine if there is an association between an early level of urinary AscOOH and later development of bronchopulmonary dysplasia (BPD) or death. Materials and Methods: This prospective cohort study included 51 infants at
ISSN:0148-6071
1941-2444
DOI:10.1177/0148607116643704