Intra-articular injections of botulinum toxin a for refractory joint pain: a systematic review and meta-analysis

Objective: To assess the benefit of intra-articular injection of Botulinum toxin A (BoNT-A) for chronic refractory joint pain regardless of joint or pathology. Data sources: The search was performed on Ovid MEDLINE(R) In-Process and Other Non-Indexed Citations, Ovid MEDLINE(R), Ovid EMBASE, Web of S...

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Bibliographic Details
Published in:Clinical rehabilitation 2017-04, Vol.31 (4), p.435-443
Main Authors: Wu, Tao, Song, Hai-xin, Dong, Yan, Ye, Ye, Li, Jian-hua
Format: Article
Language:English
Subjects:
Arthralgia - drug therapy
Arthralgia - etiology
Botulinum toxin
Botulinum toxin A
Botulinum Toxins, Type A - administration & dosage
Botulinum Toxins, Type A - therapeutic use
Chronic pain
Citations
Clinical trials
Control groups
Critical incidents
Evidence-based medicine
Group therapy
Humans
Injections, Intra-Articular
Knee
Meta-analysis
Neuromuscular Agents - administration & dosage
Neuromuscular Agents - therapeutic use
Osteoarthritis - complications
Osteoarthritis - drug therapy
Outcome Assessment (Health Care)
Pain
Pain Measurement
Pain, Intractable - drug therapy
Pain, Intractable - etiology
Pathology
Systematic review
Toxins
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Summary:Objective: To assess the benefit of intra-articular injection of Botulinum toxin A (BoNT-A) for chronic refractory joint pain regardless of joint or pathology. Data sources: The search was performed on Ovid MEDLINE(R) In-Process and Other Non-Indexed Citations, Ovid MEDLINE(R), Ovid EMBASE, Web of Science, and Scopus inception through Week 12, 2016. Trial selection: Clinical randomized controlled trials that evaluated BoNT-A intra-articular injection in patients with refractory joint pain were included. Data extraction: Two independent reviewers conducted data extraction. Results: A total of 6 out of 284 records were included. The analysis indicated that a statistically significant decreased pain score was found in BoNT-A therapy group than control group with WMD=1.10 (95% CI: 0.35 to 1.85; P
ISSN:0269-2155
1477-0873
DOI:10.1177/0269215516644951