Impact of recipient twin preoperative myocardial performance index in twin-twin transfusion syndrome treated with laser

Objective: To validate the efficacy of laser therapy for twin-twin transfusion syndrome (TTTS) in the treatment of recipient twin cardiomyopathy and investigate whether severity of preoperative cardiomyopathy can predict fetal survival postoperatively. Study design: Retrospective study of monochorio...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2017-04, Vol.30 (7), p.767-771
Main Authors: Finneran, Matthew M., Pickens, Ryan, Templin, Megan, Stephenson, Courtney D.
Format: Article
Language:English
Subjects:
Adult
Female
Fetal Heart - physiopathology
Fetal therapy
Fetofetal Transfusion - surgery
Fetoscopy - methods
Health Status Indicators
Heart Ventricles - physiopathology
Humans
laser
Laser Therapy
myocardial performance index
Myocardium - pathology
Pregnancy
Preoperative Period
recipient cardiomyopathy
Retrospective Studies
twin-twin transfusion syndrome
Twins
Ultrasonography, Prenatal
Young Adult
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Summary:Objective: To validate the efficacy of laser therapy for twin-twin transfusion syndrome (TTTS) in the treatment of recipient twin cardiomyopathy and investigate whether severity of preoperative cardiomyopathy can predict fetal survival postoperatively. Study design: Retrospective study of monochorionic-diamniotic (MCDA) pregnancies complicated by TTTS treated by selective fetoscopic laser photocoagulation (SFLP) performed between March 2010 and October 2014 at a single center. The recipient right ventricular (RV) and left ventricular (LV) myocardial performance index (MPI) were measured both pre- and postoperatively. The data were analyzed with the Wilcoxon signed rank and parametric t-tests. Results: Forty-three women met inclusion criteria during the study period. There was a substantial improvement in recipient LV (0.57 ± 0.13 versus 0.43 ± 0.13, p ≤ 0.0001) and RV (0.60 ± 0.16 versus 0.49 ± 0.18, p ≤ 0.0001) MPI postoperatively (median = 8 days). Recipient preoperative LV and RV MPI did not correlate with recipient or donor survival at 24 hours, 7 days or at birth. Thirty-seven recipients (95%) showed improvement in either LV or RV MPI and 22 (56%) showed complete resolution of cardiac dysfunction. Conclusion: Laser treatment for TTTS causes rapid improvement in the cardiac function of recipient fetuses. The severity of recipient preoperative MPI does not correlate with survival of either twin postoperatively.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2016.1187124