Synthesis of 2,3-Disubstituted Indoles and Benzofurans by the Tandem Reaction of Rhodium(II)-Catalyzed Intramolecular C–H Insertion and Oxygen-Mediated Oxidation

A highly effective and straightforward method to construct a wide range of functionalized 2,3-disubstituted indoles has been developed. The method involves the tandem reaction of rhodium­(II)-catalyzed denitrogenative annulation of triazole-based benzyl anilines and oxygen-mediated oxidative aromati...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-11, Vol.81 (21), p.10180-10192
Main Authors: Shen, Hongjuan, Fu, Junkai, Yuan, Hao, Gong, Jianxian, Yang, Zhen
Format: Article
Language:English
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Summary:A highly effective and straightforward method to construct a wide range of functionalized 2,3-disubstituted indoles has been developed. The method involves the tandem reaction of rhodium­(II)-catalyzed denitrogenative annulation of triazole-based benzyl anilines and oxygen-mediated oxidative aromatization. The developed method can also be used to synthesize 2,3-disubstituted benzofurans by replacing the benzyl anilines with benzyl phenols.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b00611