Loading…

Long‐term pulmonary function in esophageal atresia—A case‐control study

Summary Background Esophageal atresia (EA) is a congenital anomaly associated with substantial pulmonary morbidity throughout childhood. Aim The aim of this study was to evaluate pulmonary complications among 59 five to 15‐year‐old children and adolescents with surgically corrected congenital EA. Me...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric pulmonology 2017-01, Vol.52 (1), p.98-106
Main Authors: Pedersen, Rikke N., Markøw, Simone, Kruse‐Andersen, Søren, Qvist, Niels, Gerke, Oke, Husby, Steffen, Agertoft, Lone
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background Esophageal atresia (EA) is a congenital anomaly associated with substantial pulmonary morbidity throughout childhood. Aim The aim of this study was to evaluate pulmonary complications among 59 five to 15‐year‐old children and adolescents with surgically corrected congenital EA. Methods Participants underwent a structured interview, spirometry, body plethysmography, mannitol challenge test, skin prick test, as well as measurements of the diffusion capacity, airway resistance, fraction of exhaled NO, and specific immunoglobulin E in serum. A control group consisted of 25 children being evaluated for gastroesophageal reflux disease. Results Among the EA patients 33 (55.9%) had respiratory symptoms, 31 (53.4%) had a history of at least three pneumonias, and 32 (54.2%) reported more frequent cough episodes than peers. The Forced Vital Capacity (FVC) was 84.9% ± 13.2% of predicted, forced expiratory volume 1 sec (FEV1) was 78.2% ± 12.4% of predicted, and forced expiratory fraction 25–75% (FEF25–75%) was 71.5 ± 17.8% of predicted in EA patients, lower than disease controls (P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.23477