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Long‐term pulmonary function in esophageal atresia—A case‐control study
Summary Background Esophageal atresia (EA) is a congenital anomaly associated with substantial pulmonary morbidity throughout childhood. Aim The aim of this study was to evaluate pulmonary complications among 59 five to 15‐year‐old children and adolescents with surgically corrected congenital EA. Me...
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Published in: | Pediatric pulmonology 2017-01, Vol.52 (1), p.98-106 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Summary
Background
Esophageal atresia (EA) is a congenital anomaly associated with substantial pulmonary morbidity throughout childhood.
Aim
The aim of this study was to evaluate pulmonary complications among 59 five to 15‐year‐old children and adolescents with surgically corrected congenital EA.
Methods
Participants underwent a structured interview, spirometry, body plethysmography, mannitol challenge test, skin prick test, as well as measurements of the diffusion capacity, airway resistance, fraction of exhaled NO, and specific immunoglobulin E in serum. A control group consisted of 25 children being evaluated for gastroesophageal reflux disease.
Results
Among the EA patients 33 (55.9%) had respiratory symptoms, 31 (53.4%) had a history of at least three pneumonias, and 32 (54.2%) reported more frequent cough episodes than peers. The Forced Vital Capacity (FVC) was 84.9% ± 13.2% of predicted, forced expiratory volume 1 sec (FEV1) was 78.2% ± 12.4% of predicted, and forced expiratory fraction 25–75% (FEF25–75%) was 71.5 ± 17.8% of predicted in EA patients, lower than disease controls (P |
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ISSN: | 8755-6863 1099-0496 |
DOI: | 10.1002/ppul.23477 |