Anaesthetic efficacy of lidocaine/clonidine for inferior alveolar nerve block in patients with irreversible pulpitis

Aims This prospective, randomized, double‐blind study aimed to compare the efficacy of lidocaine with epinephrine versus lidocaine with clonidine for inferior alveolar nerve block (IANB) and hemodynamic stability (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressu...

Full description

Saved in:
Bibliographic Details
Published in:International endodontic journal 2017-06, Vol.50 (6), p.531-539
Main Authors: Shadmehr, E., Aminozarbian, M. G., Akhavan, A., Mahdavian, P., Davoudi, A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia, Dental - methods
Blood pressure
Clonidine
Clonidine - administration & dosage
Clonidine - therapeutic use
Dental caries
Dentistry
Double-Blind Method
Endodontics
Epinephrine
Epinephrine - administration & dosage
Epinephrine - therapeutic use
Female
Heart rate
Humans
inferior alveolar nerve block
Injections
irreversible pulpitis
Lidocaine
Lidocaine - administration & dosage
Lidocaine - therapeutic use
Male
Mandible
Mandibular Nerve - drug effects
Middle Aged
Molar - surgery
Molars
Nerve Block - methods
Pain
Pulpitis - surgery
Success
Teeth
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims This prospective, randomized, double‐blind study aimed to compare the efficacy of lidocaine with epinephrine versus lidocaine with clonidine for inferior alveolar nerve block (IANB) and hemodynamic stability (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure) in patients with irreversible pulpitis. Methodology One hundred patients with irreversible pulpitis in mandibular molar teeth randomly received 1.8 mL of 2% lidocaine with clonidine (15 μg mL−1) or 1.8 mL of 2% lidocaine with epinephrine (12.5 μg mL−1), using a conventional IANB technique. Endodontic access cavities were prepared 15 min after solution deposition, and all patients were required to have profound lip numbness. Success was defined as no or mild pain (visual analog scale recording) upon endodontic access cavity preparation or initial canal instrumentation. The hemodynamic parameters were measured before, during and 5, 10 and 30 min after administration. Finally, the collected data were subjected to independent t‐test, chi‐square and Fisher's exact test using spss software ver.20 at a significant level of 0.05. Results The success rates for IANB using lidocaine with epinephrine and lidocaine with clonidine solutions were 29% and 59%, respectively. The clonidine group exhibited a significantly higher success rate (P 
ISSN:0143-2885
1365-2591
DOI:10.1111/iej.12659