Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species

The naked mole-rat (Heterocephalus glaber) is widely acclaimed to be cancer-resistant and of considerable research interest based on a paucity of reports of neoplasia in this species. We have, however, encountered four spontaneous cases of neoplasia and one presumptive case of neoplasia through rout...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-01, Vol.72 (1), p.38-43
Main Authors: Taylor, Kyle R, Milone, Nicholas A, Rodriguez, Carlos E
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Animals
Biopsy
Carcinoma, Hepatocellular - pathology
Esophageal cancer
Esophageal Neoplasms - pathology
Hemangioma - pathology
Kidney Neoplasms - pathology
Liver Neoplasms - pathology
Lymphoma, Non-Hodgkin - pathology
Mole Rats
Rodents
Skin Neoplasms - pathology
Tumors
Wilms Tumor - pathology
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Summary:The naked mole-rat (Heterocephalus glaber) is widely acclaimed to be cancer-resistant and of considerable research interest based on a paucity of reports of neoplasia in this species. We have, however, encountered four spontaneous cases of neoplasia and one presumptive case of neoplasia through routine necropsy and biopsy of individuals in a zoo collection of nonhybrid naked mole-rats bred from a single pair. One case each of metastasizing hepatocellular carcinoma, nephroblastoma (Wilms' tumor), and multicentric lymphosarcoma, as well as presumptive esophageal adenocarcinoma (Barrett's esophagus-like) was identified postmortem among 37 nonautolyzed necropsy submissions of naked mole-rats over 1-year-old that were submitted for necropsy between 1998 and August 2015. One incidental case of cutaneous hemangioma was also identified antemortem by skin biopsy from one naked mole-rat examined for trauma.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glw047