Hyperforin-loaded gold nanoparticle alleviates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating regulatory T cells

Abstract Hyperforin an herbal compound, is commonly used in traditional medicine due to its anti-inflammatory activities. The aim of this study was to use a hyperforin loaded gold nanoparticle (Hyp-GNP) to treatment of experimental autoimmune encephalomyelitis (EAE) an animal model of multiple scler...

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Bibliographic Details
Published in:Nanomedicine 2016-10, Vol.12 (7), p.1961-1971
Main Authors: Nosratabadi, Reza, Rastin, Maryam, Sankian, Mojtaba, Haghmorad, Dariush, Mahmoudi, Mahmoud
Format: Article
Language:English
Subjects:
Animals
Encephalomyelitis, Autoimmune, Experimental - drug therapy
Experimental autoimmune encephalomyelitis (EAE)
Gold - therapeutic use
Gold nanoparticle
Hyperforin
Internal Medicine
Mice
Mice, Inbred C57BL
Multiple sclerosis
Myelin oligodendrocyte glycoprotein (MOG)
Nanoparticles
Phloroglucinol - analogs & derivatives
Phloroglucinol - therapeutic use
T-Lymphocytes, Regulatory
Terpenes - therapeutic use
Th1 Cells
Th17 Cells
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Summary:Abstract Hyperforin an herbal compound, is commonly used in traditional medicine due to its anti-inflammatory activities. The aim of this study was to use a hyperforin loaded gold nanoparticle (Hyp-GNP) to treatment of experimental autoimmune encephalomyelitis (EAE) an animal model of multiple sclerosis (MS). Hyp-GNP and hyperforin significantly reduced clinical severity of EAE, which was accompanied by a decrease in the number of inflammatory cell infiltration in the spinal cord. Additionally, treatment with Hyp-GNP significantly inhibited disease-associated cytokines as well as an increase in the anti-inflammatory cytokines in comparison to all groups including free-hyp group. Furthermore, hyperforin and Hyp-GNP inhibited the differentiation of Th1 and Th17 cells while promoted Treg and Th2 cell differentiation via regulating their master transcription factors. The current study demonstrated although, free-hyp improve clinical and laboratory data but Hyp-GNP is significantly more efficient than free hyperforin in the treatment of EAE.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2016.04.001