Semaphorin 3A, a potential immune regulator in familial Mediterranean fever

• Published in: Clinical and experimental rheumatology 2016-09, Vol.34 (6 Suppl 102), p.S52-S55
• Main Authors: Rimar, Doron, Rosner, Itzhak, Slobodin, Gleb, Rozenbaum, Michael, Halasz, Katy, Jiries, Nizar, Kaly, Lisa, Boulman, Nina, Vadasz, Zahava
• Format: Article
• Language: English
• Subjects: Adult; B-Lymphocytes, Regulatory - immunology; B-Lymphocytes, Regulatory - metabolism; Biomarkers - blood; Case-Control Studies; Disease Progression; Down-Regulation; Familial Mediterranean Fever - blood; Familial Mediterranean Fever - diagnosis; Familial Mediterranean Fever - drug therapy; Familial Mediterranean Fever - immunology; Female; Humans; Male; Middle Aged; Remission Induction; Semaphorin-3A - blood; Semaphorin-3A - immunology; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism
• ISSN: 0392-856X

Semaphorin 3A (sema3A) plays a regulatory role in immune responses with effects on both T and B regulatory cells. Familial Mediterranean fever (FMF) is an autoinflammatory disease, yet a possible role for regulatory T and B cells has been described. 17 FMF patients during attack and then in remission, 8 FMF patients with smoldering disease and 12 healthy controls were enrolled. Sema3A in serum and its expression on regulatory T and B cells was evaluated. Clinical parameters of FMF patients were assessed. Semaphorin 3A serum level was lower in FMF patients during attack, smoldering disease or remission than healthy controls, (242.3±9.8 ng/ ml vs. 258.9±11.5 ng/ml vs. 232.5±22.7 ng/ml vs. 323.3±160.2 ng/ml, respectively p