Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury

Retinal ganglion cell (RGC) injury is one of the important pathological features of diabetes-induced retinal neurodegeneration. Increasing attention has been paid to find strategies for protecting against RGC injury. Long noncoding RNAs (lncRNAs) have emerged as the key regulators of many cell funct...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2017-03, Vol.37 (2), p.361-369
Main Authors: Li, Chao-Peng, Wang, Shu-Hong, Wang, Wen-Qi, Song, Shu-Guang, Liu, Xiu-Ming
Format: Article
Language:English
Subjects:
Animals
Autoimmune diseases
Biomedical and Life Sciences
Biomedicine
Brief Communication
Cell Biology
Cell Survival - drug effects
Cell Survival - physiology
Diabetes mellitus
Diabetes Mellitus, Experimental - genetics
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Diabetic Retinopathy - genetics
Diabetic Retinopathy - metabolism
Diabetic Retinopathy - pathology
Gene Knockdown Techniques
Glucose - toxicity
Immunology
Male
Mice
Mice, Inbred C57BL
Neurobiology
Neurosciences
Retinal Ganglion Cells - metabolism
Retinal Ganglion Cells - pathology
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
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Summary:Retinal ganglion cell (RGC) injury is one of the important pathological features of diabetes-induced retinal neurodegeneration. Increasing attention has been paid to find strategies for protecting against RGC injury. Long noncoding RNAs (lncRNAs) have emerged as the key regulators of many cell functions. Here, we show that Sox2OT expression is significantly down-regulated in the retinas of STZ-induced diabetic mice and in the RGCs upon high glucose or oxidative stress. SOX2OT knockdown protects RGCs against high glucose-induced injury in vitro. Moreover, Sox2OT knockdown plays a neuroprotective role in diabetes-related retinal neurodegeneration in vivo. Sox2OT knockdown could regulate oxidative stress response in RGCs and diabetic mouse retinas. Sox2OT knockdown plays an anti-oxidative role via regulating NRF2/HO-1 signaling activity. Taken together, Sox2OT knockdown may be a therapeutic strategy for the prevention and treatment of diabetes-induced retinal neurodegeneration.
ISSN:0272-4340
1573-6830
1573-6830
DOI:10.1007/s10571-016-0380-1