Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE ε4

• Published in: Brain imaging and behavior 2017-06, Vol.11 (3), p.818-828
• Main Authors: Su, Yun Yan, Zhang, Xiao Dong, Schoepf, U. Joseph, Varga-Szemes, Akos, Stubenrauch, Andrew, Liang, Xue, Zheng, Li Juan, Zheng, Gang, Kong, Xiang, Xu, Qiang, Wang, Shou Ju, Qi, Rong Feng, Lu, Guang Ming, Zhang, Long Jiang
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Alzheimer Disease - genetics; Amyloid beta-Protein Precursor - genetics; Apolipoprotein E2 - genetics; Apolipoprotein E4 - genetics; Biomedical and Life Sciences; Biomedicine; Brain - diagnostic imaging; Brain - physiology; Brain Mapping; Female; Genetic Predisposition to Disease; Heterozygote; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Mutation; Neural Pathways - diagnostic imaging; Neural Pathways - physiology; Neuropsychological Tests; Neuropsychology; Neuroradiology; Neurosciences; Original Research; Presenilin-1 - genetics; Presenilin-2 - genetics; Psychiatry; Rest; Young Adult
• ISSN: 1931-7557; 1931-7565
• DOI: 10.1007/s11682-016-9556-z

In this study, we used resting-state functional magnetic resonance imaging to explore the genetic effects of amyloid precursor protein ( APP ) or presenilins mutation and apolipoprotein E ( APOE ) ε4 on the default-mode network (DMN) in cognitively intact young adults (24.1 ± 2.5 years). Both the APP or presenilin-1 / 2 group and the APOE ε4 group had significantly lower DMN functional connectivity (FC) in the some brain regions like precuneus/middle cingulate cortices (PCu/MCC) than controls (AlphaSim corrected, P