Multi-polydioxanone (PDO) scaffold for forehead wrinkle correction: A pilot study

Forehead wrinkles are the result of contracture of the frontalis muscle and the skin aging process. Currently, hyaluronic acid filler and botulinum toxin are the main materials used for correction of these wrinkles. In addition, polydioxanone (PDO) thread has also been applied for this treatment. In...

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Bibliographic Details
Published in:Journal of cosmetic and laser therapy 2016-11, Vol.18 (7), p.405-408
Main Authors: Ko, Hyun Ju, Choi, Joon Yong, Moon, Hyoung Jin, Lee, Jin Woo, Jang, Sue Im, Bae, Il-Hong, Choi, Jin Kyu, Kim, Hyuk, Park, Won-Seok, Oh, Won Jong, Choi, Sun Young, Kim, Beom Joon
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Female
Forehead - surgery
Guided Tissue Regeneration - methods
Humans
Pilot Projects
Polydioxanone - administration & dosage
Swine
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Summary:Forehead wrinkles are the result of contracture of the frontalis muscle and the skin aging process. Currently, hyaluronic acid filler and botulinum toxin are the main materials used for correction of these wrinkles. In addition, polydioxanone (PDO) thread has also been applied for this treatment. In order to evaluate the efficacy and safety of multi-PDO scaffold in animal and human skin, we tested PDO insertion in rat and mini-pig models and human volunteers with forehead wrinkles. A stent-shaped multi-PDO scaffold was inserted under the panniculus carnosus of rat dorsal skin and the subcutaneous layer of mini-pig dorsal skin and forehead wrinkles in three human volunteers. Histological analysis at 12 weeks revealed evidence of de novo collagen synthesis, which was consistent with clinical results on photo evaluation. Stent-shaped multi-PDO scaffolds may be another effective and safe treatment modality for reduction of forehead wrinkles.
ISSN:1476-4172
1476-4180
DOI:10.1080/14764172.2016.1191643