Hypoglycemic potential of herbal product dolabi compared with pioglitazone in streptozotocin-induced diabetic rats

To investigate and compare the hypoglycemic potential of commonly used polyherbal formulation dolabi with pioglitazone in streptozotocin-induced diabetic rats. A total of 24 adult male Wistar rats were randomized into diabetic control group, diabetic group receiving dolabi (17.6 mg kg day ), diabeti...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2016-05
Main Authors: Rahman, Inayat Ur, Idrees, Muhammad, Rahman, Khalil Ur, Khan, Muhammad Iqbal, Jan, Naeem Ullah
Format: Article
Language:English
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Summary:To investigate and compare the hypoglycemic potential of commonly used polyherbal formulation dolabi with pioglitazone in streptozotocin-induced diabetic rats. A total of 24 adult male Wistar rats were randomized into diabetic control group, diabetic group receiving dolabi (17.6 mg kg day ), diabetic group receiving dolabi (35.2 mg kg day ) and diabetic group receiving pioglitazone (2.7 mg kg day ), with 6 rats in each group. The study was conducted for 4 weeks. Blood samples were collected for fructosamine estimation, fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT) were measured at different time points. Compared with baseline, the groups receiving dolabi (35.2 mg kg day ) and pioglitazone showed signififi cant reductions (P
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-016-2583-1