Evidence for potential involvement of pro-inflammatory adipokines in the pathogenesis of idiopathic intracranial hypertension

• Published in: Cephalalgia 2017-05, Vol.37 (6), p.525-531
• Main Authors: Samancı, Bedia, Samancı, Yavuz, Tüzün, Erdem, Altıokka-Uzun, Güneş, Ekizoğlu, Esme, İçöz, Sema, Şahin, Erdi, Küçükali, Cem İsmail, Baykan, Betül
• Format: Article
• Language: English
• Subjects: Adipokines - blood; Adult; Biomarkers - blood; Female; Humans; Inflammation Mediators - blood; Magnetic Resonance Angiography - methods; Magnetic Resonance Imaging - methods; Male; Middle Aged; Pseudotumor Cerebri - blood; Pseudotumor Cerebri - diagnostic imaging
• ISSN: 0333-1024; 1468-2982
• DOI: 10.1177/0333102416650705

Background Although specific role players are currently unknown, contribution of inflammatory mediators has been suggested in the pathophysiology of idiopathic intracranial hypertension (IIH), which is a disease more prevalent in obese female individuals of childbearing age. We aimed to investigate the levels of adipokines and cytokines to demonstrate possible markers for inflammation that participate in IIH pathophysiology and their association with clinical features of IIH. Methods IIH patients, diagnosed according to the revised criteria, and age-, gender- and body mass index (BMI)-matched healthy controls were enrolled in this study. Serum samples were evaluated for insulin-like growth factor 1, insulin, nesfatin, adiponectin, interleukin (IL)-1β, IL-6, IL-8, leptin, plasminogen activator inhibitor type-1, resistin, tumour necrosis factor-alpha (TNF-α) and monocyte chemotactic protein 1 via enzyme-linked immunosorbent assay or multiplex immunoassays. Results IL-1β level was significantly higher (p = 0.012), and IL-8 and TNF-α levels were significantly lower in the IIH group (p