Topical delivery of 4-hexylresorcinol promotes wound healing via tumor necrosis factor-α suppression

Highlights • Burn wound healing mechanism for 4-hexylresorcinol (4HR) is proposed. • The expression of TNF-α was inhibited by 4HR in RAW264.7 cells. • The ointment containing 4HR displayed less TNF-α expression after burn. • The 4HR contained ointment showed rapid epithelization.

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Bibliographic Details
Published in:Burns 2016-11, Vol.42 (7), p.1534-1541
Main Authors: Ahn, Janghoon, Kim, Seong-Gon, Kim, Min-Keun, Kim, Dae-Won, Lee, Jang-Ha, Seok, Hyun, Choi, Je-Yong
Format: Article
Language:English
Subjects:
4-Hexylresorcinol
Administration, Cutaneous
Administration, Topical
Animals
Anthelmintics - pharmacology
Blotting, Western
Burn
Burns - drug therapy
Burns - metabolism
Critical Care
Epithelization
Hexylresorcinol - pharmacology
Immunohistochemistry
Male
Mice
Ointments
Rats
Rats, Wistar
RAW 264.7 Cells
Re-Epithelialization - drug effects
TNF-α
Tumor Necrosis Factor-alpha - drug effects
Tumor Necrosis Factor-alpha - metabolism
Wound Healing - drug effects
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Description
Summary:Highlights • Burn wound healing mechanism for 4-hexylresorcinol (4HR) is proposed. • The expression of TNF-α was inhibited by 4HR in RAW264.7 cells. • The ointment containing 4HR displayed less TNF-α expression after burn. • The 4HR contained ointment showed rapid epithelization.
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2016.04.016