Vitreous metastasis of malignant cutaneous melanoma during treatment with ipilimumab

An isolated metastasis of the vitreous body from a malignant cutaneous melanoma without involvement of the choroid is an extremely rare occurrence. We report on the case of a 59-year-old female patient who presented with a vitreous body metastasis during systemic treatment with the anti-cytotoxic T...

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Bibliographic Details
Published in:Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 2017-02, Vol.114 (2), p.163-166
Main Authors: Kellermann, N, Maier, M, Feucht, N
Format: Article
Language:ger
Subjects:
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
Diagnosis, Differential
Eye Neoplasms - chemically induced
Eye Neoplasms - pathology
Eye Neoplasms - secondary
Female
Humans
Ipilimumab
Melanoma - chemically induced
Melanoma - pathology
Middle Aged
Skin Neoplasms - complications
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Treatment Outcome
Vitreous Body - drug effects
Vitreous Body - pathology
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Description
Summary:An isolated metastasis of the vitreous body from a malignant cutaneous melanoma without involvement of the choroid is an extremely rare occurrence. We report on the case of a 59-year-old female patient who presented with a vitreous body metastasis during systemic treatment with the anti-cytotoxic T lymphocyte-associated antigen (anti-CTLA 4) antibody ipilimumab. This case report underlines the diagnostic difficulties in such cases and points out the risk of metastasis in immune-privileged sites under systemic immunotherapy.
ISSN:1433-0423
DOI:10.1007/s00347-016-0271-3