Cell reprogramming during regeneration in Drosophila : transgression of compartment boundaries

We discuss recent work about cellular reprogramming during regeneration of the imaginal discs of Drosophila . These contain various lineage blocks, compartments, which express distinct genetic programmes. It has been found that after massive damage to a compartment cells from a neighbour compartment...

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Bibliographic Details
Published in:Current opinion in genetics & development 2016-10, Vol.40, p.11-16
Main Authors: Morata, Ginés, Herrera, Salvador C
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation - genetics
Cell Transdifferentiation - genetics
Cellular Reprogramming - genetics
Drosophila
Epigenesis, Genetic
Imaginal Discs - growth & development
MAP Kinase Signaling System - genetics
Medical Education
Polycomb-Group Proteins - genetics
Regeneration - genetics
Wings, Animal - growth & development
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Summary:We discuss recent work about cellular reprogramming during regeneration of the imaginal discs of Drosophila . These contain various lineage blocks, compartments, which express distinct genetic programmes. It has been found that after massive damage to a compartment cells from a neighbour compartment can transgress the compartment border and contribute to its regeneration. The transgressing cells are genetically reprogrammed and acquire a new identity, a process facilitated by up regulation of the JNK pathway and transient loss of epigenetic control by the Pc-G and trx-G genes. The final acquisition of the new identity appears to be mediated by induction by neighbour cells, a phenomenon akin the Community Effect described for the specification of amphibian muscle cells.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2016.05.008