Basophil activation test determination of CD63 combined with CD203c is not superior to CD203c alone in identifying allergic bronchopulmonary aspergillosis in cystic fibrosis

The same results were obtained after 30 minutes of ex vivo stimulation with A fumigatus extract (data not shown). [...]from this study, allergen-induced BAT CD203c surface upregulation appears to be a sufficient single biomarker for diagnostic purposes, and does not require additional measurement of...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-10, Vol.138 (4), p.1195-1196
Main Authors: Gernez, Yael, MD, PhD, Waters, Jeffrey, MSc, Tirouvanziam, Rabindra, PhD, Herzenberg, Leonore, PhD, Moss, Richard, MD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Cystic fibrosis
Flow cytometry
Food allergies
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Summary:The same results were obtained after 30 minutes of ex vivo stimulation with A fumigatus extract (data not shown). [...]from this study, allergen-induced BAT CD203c surface upregulation appears to be a sufficient single biomarker for diagnostic purposes, and does not require additional measurement of CD63 to identify ABPA and/or A fumigatus colonization in patients with CF.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.04.002