N-acetylcysteine supplementation reduces oxidative stress for cytosine arabinoside in rat model

Cytosine arabinoside (ARA-C) is a pyrimidine analog that may cause keratoconjunctivitis when used in high doses. The underlying mechanism may be the increased amounts of reactive oxygen radicals that may damage the DNA synthesis of corneal and conjunctival epithelial cells. Topical corticosteroids a...

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Bibliographic Details
Published in:International ophthalmology 2017-02, Vol.37 (1), p.209-214
Main Authors: Balci, Yasemin Isik, Acer, Semra, Yagci, Ramazan, Kucukatay, Vural, Sarbay, Hakan, Bozkurt, Kerem, Polat, Aziz
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Animals
Antioxidants - metabolism
Conjunctiva - drug effects
Cornea - drug effects
Cytarabine - pharmacology
Dietary Supplements
Disease Models, Animal
Free Radical Scavengers - pharmacology
Immunosuppressive Agents - pharmacology
Medicine
Medicine & Public Health
Ophthalmology
Original Paper
Oxidative Stress - drug effects
Rats
Rats, Wistar
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Summary:Cytosine arabinoside (ARA-C) is a pyrimidine analog that may cause keratoconjunctivitis when used in high doses. The underlying mechanism may be the increased amounts of reactive oxygen radicals that may damage the DNA synthesis of corneal and conjunctival epithelial cells. Topical corticosteroids are one of the prophylactic treatments for keratoconjunctivitis induced by ARA-C. Forty Wistar-type albino rats were included in this study the rats were divided into four groups. The first group (Group 1) received only ARA-C, the second group (Group 2) received ARA-C and N -acetylcysteine (NAC), the third group (Group 3) received only NAC and the fourth group (Group 4) was the control group. The total oxidant status (TOS), the total antioxidant capacity and the oxidative stress index (OSI) measurements of the cornea and the conjunctiva were evaluated in these four groups. The mean TOS and OSI value was the highest in Group 1 and the lowest in Group 3. The differences in TOS and OSI values were statistically significant between Group 1 and Group 2. There are decreases in TOS and OSI values in rats which received ARA-C with NAC administration. NAC may have a protective effect on ARA-C-induced keratoconjunctivitis.
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-016-0259-7