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Mannitol clearance for the determination of glomerular filtration rate-a validation against clearance of 51 Cr-EDTA
We studied the agreement between plasma clearance of mannitol and the reference method, plasma clearance of Cr-EDTA in outpatients with normal to moderately impaired renal function. Forty-one patients with a serum creatinine
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| Published in: | Clinical physiology and functional imaging 2018-01, Vol.38 (1), p.10-16 |
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| Main Authors: | , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c1301-6fa808d5751eac27890777616a9bb571ad3c62153687a448cdcf81e2d2b921d93 |
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| cites | cdi_FETCH-LOGICAL-c1301-6fa808d5751eac27890777616a9bb571ad3c62153687a448cdcf81e2d2b921d93 |
| container_end_page | 16 |
| container_issue | 1 |
| container_start_page | 10 |
| container_title | Clinical physiology and functional imaging |
| container_volume | 38 |
| creator | Kiss, Katalin Molnár, Miklós Söndergaard, Sören Molnár, Gyula Ricksten, Sven-Erik |
| description | We studied the agreement between plasma clearance of mannitol and the reference method, plasma clearance of
Cr-EDTA in outpatients with normal to moderately impaired renal function. Forty-one patients with a serum creatinine |
| doi_str_mv | 10.1111/cpf.12374 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826696165</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826696165</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1301-6fa808d5751eac27890777616a9bb571ad3c62153687a448cdcf81e2d2b921d93</originalsourceid><addsrcrecordid>eNpNkE9PwzAMxSMEYmNw4AugHOHQEadt0h6nMf5IQ1yGxK1y02QUpe1IWiS-PYHChC_Psp-f5B8h58DmEOpa7cwceCyTAzKFRKYRy-XL4b4XMCEn3r8xBjJO5DGZcMlTkXOYEv-IbVv3naXKanTYKk1N52j_qmmle-2ausW-7lraGbq1XaPdYNFRU9vejYsgOkL6gbauxglusW59_y8yHKdAly5a3WwWp-TIoPX67Fdn5Pl2tVneR-unu4flYh0piBlEwmDGsiqVKWhUXGY5k1IKEJiXZSoBq1gJDmksMolJkqlKmQw0r3gZXqvyeEYux9yd694H7fuiqb3S1mKru8EXkHEhAh2RBuvVaFWu895pU-xc3aD7LIAV34yLwLj4YRy8F7-xQ9noau_8gxp_AVkMdvk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826696165</pqid></control><display><type>article</type><title>Mannitol clearance for the determination of glomerular filtration rate-a validation against clearance of 51 Cr-EDTA</title><source>Wiley</source><creator>Kiss, Katalin ; Molnár, Miklós ; Söndergaard, Sören ; Molnár, Gyula ; Ricksten, Sven-Erik</creator><creatorcontrib>Kiss, Katalin ; Molnár, Miklós ; Söndergaard, Sören ; Molnár, Gyula ; Ricksten, Sven-Erik</creatorcontrib><description>We studied the agreement between plasma clearance of mannitol and the reference method, plasma clearance of
Cr-EDTA in outpatients with normal to moderately impaired renal function. Forty-one patients with a serum creatinine <200 μmol l
entered the study.
Cr-EDTA clearance was measured with the standard bolus injection technique and glomerular filtration rate (GFR) was calculated by the single-sample method described by Jacobsson. Mannitol, 0·25 g kg
body weight (150 mg ml
), was infused for 4-14 min and blood samples taken at 1-, 2-, 3- and 4-h (n = 24) or 2-, 3-, 3·5- and 4-h after infusion (n = 17). Mannitol in serum was measured by an enzymatic method. Plasma clearance for mannitol and its apparent volume of distribution (Vd) were calculated according to Brøchner-Mortensen. Mean plasma clearance (±SD) for
Cr-EDTA was 59·7 ± 18·8 ml min
. The mean plasma clearance for mannitol ranged between 57·0 ± 20·1 and 61·1 ± 16·7 ml min
and Vd was 21·3 ± 6·2% per kg b.w. The between-method bias ranged between -0·23 and 2·73 ml min
, the percentage error between 26·7 and 39·5% and the limits of agreement between -14·3/17·2 and -25·3/19·9 ml min
. The best agreement was seen when three- or four-sample measurements of plasma mannitol were obtained and when sampling started 60 min after injection. Furthermore, accuracy of plasma clearance determinations was 88-96% (P30) and 41-63% (P10) and was highest when three- or four-sample measurements of plasma mannitol were obtained, including the first hour after the bolus dose. We conclude that there is a good agreement between plasma clearances of mannitol and
Cr-EDTA for the assessment of GFR.</description><identifier>ISSN: 1475-0961</identifier><identifier>EISSN: 1475-097X</identifier><identifier>DOI: 10.1111/cpf.12374</identifier><identifier>PMID: 27256921</identifier><language>eng</language><publisher>England</publisher><ispartof>Clinical physiology and functional imaging, 2018-01, Vol.38 (1), p.10-16</ispartof><rights>2016 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1301-6fa808d5751eac27890777616a9bb571ad3c62153687a448cdcf81e2d2b921d93</citedby><cites>FETCH-LOGICAL-c1301-6fa808d5751eac27890777616a9bb571ad3c62153687a448cdcf81e2d2b921d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27256921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiss, Katalin</creatorcontrib><creatorcontrib>Molnár, Miklós</creatorcontrib><creatorcontrib>Söndergaard, Sören</creatorcontrib><creatorcontrib>Molnár, Gyula</creatorcontrib><creatorcontrib>Ricksten, Sven-Erik</creatorcontrib><title>Mannitol clearance for the determination of glomerular filtration rate-a validation against clearance of 51 Cr-EDTA</title><title>Clinical physiology and functional imaging</title><addtitle>Clin Physiol Funct Imaging</addtitle><description>We studied the agreement between plasma clearance of mannitol and the reference method, plasma clearance of
Cr-EDTA in outpatients with normal to moderately impaired renal function. Forty-one patients with a serum creatinine <200 μmol l
entered the study.
Cr-EDTA clearance was measured with the standard bolus injection technique and glomerular filtration rate (GFR) was calculated by the single-sample method described by Jacobsson. Mannitol, 0·25 g kg
body weight (150 mg ml
), was infused for 4-14 min and blood samples taken at 1-, 2-, 3- and 4-h (n = 24) or 2-, 3-, 3·5- and 4-h after infusion (n = 17). Mannitol in serum was measured by an enzymatic method. Plasma clearance for mannitol and its apparent volume of distribution (Vd) were calculated according to Brøchner-Mortensen. Mean plasma clearance (±SD) for
Cr-EDTA was 59·7 ± 18·8 ml min
. The mean plasma clearance for mannitol ranged between 57·0 ± 20·1 and 61·1 ± 16·7 ml min
and Vd was 21·3 ± 6·2% per kg b.w. The between-method bias ranged between -0·23 and 2·73 ml min
, the percentage error between 26·7 and 39·5% and the limits of agreement between -14·3/17·2 and -25·3/19·9 ml min
. The best agreement was seen when three- or four-sample measurements of plasma mannitol were obtained and when sampling started 60 min after injection. Furthermore, accuracy of plasma clearance determinations was 88-96% (P30) and 41-63% (P10) and was highest when three- or four-sample measurements of plasma mannitol were obtained, including the first hour after the bolus dose. We conclude that there is a good agreement between plasma clearances of mannitol and
Cr-EDTA for the assessment of GFR.</description><issn>1475-0961</issn><issn>1475-097X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpNkE9PwzAMxSMEYmNw4AugHOHQEadt0h6nMf5IQ1yGxK1y02QUpe1IWiS-PYHChC_Psp-f5B8h58DmEOpa7cwceCyTAzKFRKYRy-XL4b4XMCEn3r8xBjJO5DGZcMlTkXOYEv-IbVv3naXKanTYKk1N52j_qmmle-2ausW-7lraGbq1XaPdYNFRU9vejYsgOkL6gbauxglusW59_y8yHKdAly5a3WwWp-TIoPX67Fdn5Pl2tVneR-unu4flYh0piBlEwmDGsiqVKWhUXGY5k1IKEJiXZSoBq1gJDmksMolJkqlKmQw0r3gZXqvyeEYux9yd694H7fuiqb3S1mKru8EXkHEhAh2RBuvVaFWu895pU-xc3aD7LIAV34yLwLj4YRy8F7-xQ9noau_8gxp_AVkMdvk</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Kiss, Katalin</creator><creator>Molnár, Miklós</creator><creator>Söndergaard, Sören</creator><creator>Molnár, Gyula</creator><creator>Ricksten, Sven-Erik</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201801</creationdate><title>Mannitol clearance for the determination of glomerular filtration rate-a validation against clearance of 51 Cr-EDTA</title><author>Kiss, Katalin ; Molnár, Miklós ; Söndergaard, Sören ; Molnár, Gyula ; Ricksten, Sven-Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1301-6fa808d5751eac27890777616a9bb571ad3c62153687a448cdcf81e2d2b921d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiss, Katalin</creatorcontrib><creatorcontrib>Molnár, Miklós</creatorcontrib><creatorcontrib>Söndergaard, Sören</creatorcontrib><creatorcontrib>Molnár, Gyula</creatorcontrib><creatorcontrib>Ricksten, Sven-Erik</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical physiology and functional imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiss, Katalin</au><au>Molnár, Miklós</au><au>Söndergaard, Sören</au><au>Molnár, Gyula</au><au>Ricksten, Sven-Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mannitol clearance for the determination of glomerular filtration rate-a validation against clearance of 51 Cr-EDTA</atitle><jtitle>Clinical physiology and functional imaging</jtitle><addtitle>Clin Physiol Funct Imaging</addtitle><date>2018-01</date><risdate>2018</risdate><volume>38</volume><issue>1</issue><spage>10</spage><epage>16</epage><pages>10-16</pages><issn>1475-0961</issn><eissn>1475-097X</eissn><abstract>We studied the agreement between plasma clearance of mannitol and the reference method, plasma clearance of
Cr-EDTA in outpatients with normal to moderately impaired renal function. Forty-one patients with a serum creatinine <200 μmol l
entered the study.
Cr-EDTA clearance was measured with the standard bolus injection technique and glomerular filtration rate (GFR) was calculated by the single-sample method described by Jacobsson. Mannitol, 0·25 g kg
body weight (150 mg ml
), was infused for 4-14 min and blood samples taken at 1-, 2-, 3- and 4-h (n = 24) or 2-, 3-, 3·5- and 4-h after infusion (n = 17). Mannitol in serum was measured by an enzymatic method. Plasma clearance for mannitol and its apparent volume of distribution (Vd) were calculated according to Brøchner-Mortensen. Mean plasma clearance (±SD) for
Cr-EDTA was 59·7 ± 18·8 ml min
. The mean plasma clearance for mannitol ranged between 57·0 ± 20·1 and 61·1 ± 16·7 ml min
and Vd was 21·3 ± 6·2% per kg b.w. The between-method bias ranged between -0·23 and 2·73 ml min
, the percentage error between 26·7 and 39·5% and the limits of agreement between -14·3/17·2 and -25·3/19·9 ml min
. The best agreement was seen when three- or four-sample measurements of plasma mannitol were obtained and when sampling started 60 min after injection. Furthermore, accuracy of plasma clearance determinations was 88-96% (P30) and 41-63% (P10) and was highest when three- or four-sample measurements of plasma mannitol were obtained, including the first hour after the bolus dose. We conclude that there is a good agreement between plasma clearances of mannitol and
Cr-EDTA for the assessment of GFR.</abstract><cop>England</cop><pmid>27256921</pmid><doi>10.1111/cpf.12374</doi><tpages>7</tpages></addata></record> |
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| title | Mannitol clearance for the determination of glomerular filtration rate-a validation against clearance of 51 Cr-EDTA |
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