Obesity is an independent prognostic factor of decreased pathological complete response to neoadjuvant chemotherapy in breast cancer patients

Abstract Purpose The relation between higher body mass index (BMI) and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer (BC) is a controversial issue according to the data of Western and Asian patients. The aim of this study is to evaluate BMI and pCR to NAC an...

Full description

Saved in:
Bibliographic Details
Published in:Breast (Edinburgh) 2017-04, Vol.32, p.237-244
Main Authors: Karatas, Fatih, Erdem, Gokmen Umut, Sahin, Suleyman, Aytekin, Aydin, Yuce, Deniz, Sever, Ali R, Babacan, Taner, Ates, Ozturk, Ozisik, Yavuz, Altundag, Kadri
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Body Mass Index
Breast cancer
Breast Neoplasms - complications
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Chemotherapy, Adjuvant - mortality
Disease-Free Survival
Female
Hematology, Oncology and Palliative Medicine
Humans
Kaplan-Meier Estimate
Logistic Models
Middle Aged
Multivariate Analysis
Neoadjuvant chemotherapy
Neoadjuvant Therapy - mortality
Neoplasm Recurrence, Local - mortality
Neoplasm Staging
Obesity - complications
Pathological complete response
Prognosis
Retrospective Studies
Survival
Treatment Outcome
Turkey
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Purpose The relation between higher body mass index (BMI) and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer (BC) is a controversial issue according to the data of Western and Asian patients. The aim of this study is to evaluate BMI and pCR to NAC and discuss the importance of pCR outcomes in Turkish BC patients as a bridging country between Europe and Asia. Patients and methods Of the 4423 BC patients diagnosed between the years 1994 and 2015 in Hacettepe University Cancer Institute, 295 female patients with stage II and III BC were enrolled in the study. Three different group divisions were done according to patients' BMI as normal or underweight (N/U) patients (BMI
ISSN:0960-9776
1532-3080
DOI:10.1016/j.breast.2016.05.013